Blockade of miR-140-3p prevents functional deterioration in afterload-enhanced engineered heart tissue
Abstract Afterload enhancement (AE) of rat engineered heart tissue (EHT) in vitro leads to a multitude of changes that in vivo are referred White Noise Machines to as pathological cardiac hypertrophy: e.g., cardiomyocyte hypertrophy, contractile dysfunction, reactivation of fetal genes and fibrotic changes.Moreover AE induced the upregulation of 22